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Genetic eligibility criteriaFor unambiguous determination, polymorphisms of CYP2C19 needed to be designated by their NCBI dbSNP identifiers (“rs numbers”), their nucleotide exchange, or their common harmonised star allele nomenclature. We considered reports on the loss of function (reduced function) variants CYP2C192 (rs4244285), CYP2C193 (rs4986893), CYP2C194 (rs28399504), CYP2C195 (rs56337013), CYP2C196 (rs72552267), CYP2C197 (rs72558186), or CYP2C198 (rs41291556), and the gain of function variant CYP2C1917 (rs12248560). The variant gene carrier status was required to be given as the distribution of genotypes among patients with and without the outcome event or as the number of individuals carrying at least one loss of function or gain of function allele. Studies reporting associations with a loss of function variant were eligible if they had genotyped at least the CYP2C192 allele because it accounts for more than 95% of the loss of function allele carrier status in white and black African populations and for more than 75% in Asian populations.26

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